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Volume 8, Issue 1, January 2020, Page: 1-5
Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae)
Issa Karama, Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso
Moussa Compaoré, Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso
Abdoulaye Djandé, Department of Chemistry, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso
Orokia Traoré, Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso
Latifou Lagnika, Department of Biochemistry and Cell Biology, University of Abomey-calavi, Cotonou, Benin
Martin Kiendrebeogo, Department of Biochemistry and Microbiology, University Joseph Ki-Zerbo, Ouagadougou, Burkina Faso
Received: Jan. 29, 2020;       Accepted: Feb. 19, 2020;       Published: Feb. 28, 2020
DOI: 10.11648/j.ajbio.20200801.11      View  466      Downloads  198
Abstract
The discovery of new molecules for fighting against malaria is still relevant to overcome Plasmodium sp resistance. Phenolic compounds from medicinal plants have shown antiplasmodial properties. In addition, the targets of flavonoids on P. falciparum are multiple. This work aimed to identify the antiplasmodial compounds from methanol extract of Securidaca longepedunculata leaves. The inhibition of β-hematin formation was used to detect antiplasmodial compounds through a bio-guided chromatographic fractionation procedures. W2 strain was inhibited by flavonoids fractions Fc1 and Fb4 with 6.98 and 10.39 µg/mL as IC50 respectively. Also, fractions of phenol acids have shown good activities on the inhibition of β-hematin formation. The HPLC analyze showed that S. longepedunculata leaves extract contained quercetin, 3-β-quercetin, luteolin, chrysin, isorhamnetin, hyperoside, rutin, gallic acid, ellagic acid, chlorogenic acid, tannic acid and ferulic acid. Among these compounds identified, some had shown antiplasmodial and inhibitory activities on the formation of β-hematin. The antimalarial activity of the leaves of S. longepedunculata would be due in part to phenolic acids and flavonoids. The antiplasmodial activity observed in this work would be due in part to the ability of flavonoids from S. longepedunculata leaves to inhibit the formation of β-hematin. This finding could justify partially the S. longepedunculata uses in malaria treatment in Burkina Faso.
Keywords
Securidaca longepedunculata, Flavonoids, Phenolic Acids, β-hematin, Antiplasmodial
To cite this article
Issa Karama, Moussa Compaoré, Abdoulaye Djandé, Orokia Traoré, Latifou Lagnika, Martin Kiendrebeogo, Antiplasmodial Activities of Flavonoids from Leaves of Securidaca longepedunculata Fresen (Polygalaceae), American Journal of BioScience. Vol. 8, No. 1, 2020, pp. 1-5. doi: 10.11648/j.ajbio.20200801.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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